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Update on the Age-Related Macular Degeneration (AMD) Drug …

AT A GLANCE. • Standard of care treatment of wet AMD typically requires long-term intravitreal anti-VEGF injections at regular intervals. • X-82 is an orally administered small-molecule tyrosine kinase inhibitor derived from a cancer drug that inhibits VEGF and PDGF receptors without the toxicities of the parent drug. See more Following promising preclinical experiments and a phase 1 study, X-82 (Tyrogenex) is being investigated in a double-masked, placebo-controlled phase 2 study as an oral … See more Phase 1 A phase 1 study of X-82 enrolled 35 patients with wet AMD.4 This was an ascending repeated-dose study. A total of six dose regimens … See more In vitro and animal experiments showed that X-82 is a potent inhibitor of vessel proliferation and provided proof of concept of its potential in retinal disease. Experiments in … See more X-82 has shown promise as a potential oral therapy for the treatment of wet AMD in a phase 1 study. Treatment-refractory and treatment-naïve patients maintained or improved visual acuity and SD-OCT findings with few or … See more WebAug 16, 2024 · August 16, 2024. Currently, many patients with wet age-related macular degeneration (AMD) require monthly injections into the eye to preserve their vision. Those with advanced dry AMD, also called geographic atrophy (GA), have no effective treatments available to them. Fortunately, AMD research and drug developments are advancing … rbc canadian equity income-f

Tuberculosis - Diagnosis and treatment - Mayo Clinic

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