Web16 apr. 2024 · Hepatocyte and liver transplantation are effective for severe liver diseases. However, many patients are unable to receive transplants due to a lack of donors. Hepatocyte-like cells, which are generated from human embryonic stem (ES)/induced pluripotent stem (iPS) cells with infinite proliferation potential, are expected to be used as … Web6 mrt. 2024 · To examine hepatoblast differentiation efficiency, the percentages of hepatoblast markers (CK19, AFP, and epithelial cell adhesion molecule (EpCAM)) …
人肝胆肿瘤细胞类器官的构建与保藏操作指南 …
Web10 jul. 2024 · 近期,北大-清华生命科学联合中心、北京大学生命科学学院徐成冉课题组在《Hepatology》(《肝脏学》)杂志上发表了题为“ A single-cell transcriptomic analysis … Web19 nov. 2015 · The aim of this study was to investigate an in vivo model to analyze hepatoblast bipotency and proliferative ability. Methods Hepatic transplantation model using Cre-inducible diphtheria toxin receptor-transgenic mice (iDTR), and albafp Cre mice expressing Cre under the control of albumin and α-fetoprotein (AFP) regulatory elements … oughtrington preschool
徐成冉课题组解析成肝细胞分化途径和调控机制-北京大学前沿交叉 …
Web1 jan. 2014 · To clarify this relationship, we examined whether c/EBPs could determine the hepatoblast fate decision via regulation of TGFβ receptor 2 (TGFBR2) expression in the hepatoblast-like cells differentiated from hESCs. We found that TGFBR2 promoter activity was negatively regulated by c/EBPα and positively regulated by c/EBPβ. Web25 aug. 2024 · c Violin and box plot of the computed c. Hepatoblast I, d Hepatoblast II, e Erythroid-like, f DCN-high, and g Neuroendocrine tumor signature scores for all nine patients (N = 6244 cells). WebThe aim of this proposal is to analyze the molecular and cellular events leading to progenitor cell (hepatoblast) and hepatocyte formation, in embryonic liver explant cultures. Although first described over explant cultures have not been clearly defined. We have successful established this in vitro system established this in vitro system and ... ought rym