WebOct 1, 2015 · Klotho is a transmembrane protein containing two internal repeats, KL1 and KL2, both displaying significant homology to members of the β-glycosidase family. Klotho … WebApr 13, 2024 · Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding tumor microenvironment (TME), composed of a myriad of cell types and biophysical and biochemical components. Fibroblasts are integral in maintaining tissue homeostasis. However, even before a tumor develops, pro-tumorigenic fibroblasts in …
Klotho‐mediated targeting of CCL2 suppresses the induction …
WebApr 12, 2024 · Transcription factors (e.g., Smad3 and NF-κB) downregulate Klotho and PGC-1α expression, whereas PGC-1α expression is promoted by histone crotonylation. A comprehensive understanding of these mediators might contribute to the establishment of novel therapeutic approaches towards CKD prevention and progression . The mechanism … WebThe Klotho promoter gene is generally hypermethylated in cancer, and overexpression or supplementation of Klotho has been found to inhibit tumor growth in various animal models. This review focuses on the protective effects of soluble Klotho in inhibiting renal fibrosis and fibrosis in distant organs secondary to renal Klotho deficiency. famous people who died in their 30s
Klotho and the Treatment of Human Malignancies - ResearchGate
WebOct 1, 2015 · In humans, α-Klotho deficiency or functional variants of α-Klotho are associated with the development of vascular calcification (11, 17), atherosclerosis , diabetes , hypertension , chronic kidney disease , osteoporosis , anemia , and various cancers such as hepatocellular carcinoma , breast cancer , gastric cancer , and renal cell carcinoma . WebKlotho, a natural human protein has great potential to delay these diseases of aging. Loss of cognition, kidney failure, diabetes, and cancer are all things that are believed to be … Web2 days ago · Cancer patients, due to their immunocompromised status, are at an increased risk for severe SARS-CoV-2 infection. Since severe SARS-CoV-2 infection causes multiple organ damage through IL-6-mediated inflammation while stimulating hypoxia, and malignancy promotes hypoxia-induced cellular metabolic alterations leading to cell death, … copy of my registration mi