2024 Meg3 gene function

Meg3 gene function

Author: pklu

August undefined, 2024

Web24 aug. 2007 · MEG3 is a maternally expressed imprinted gene suggested to function as a non-coding RNA. Our previous studies suggest that MEG3 has a function of tumor … Web1 nov. 2003 · The MEG3 cDNA isoform MEG3a (see Fig. 1A for sequence), obtained from the library screening, was cloned into pCI-neo (Promega, Madison, WI) via the 5′-EcorRI …

MEG3: an Oncogenic Long Non-coding RNA in Different Cancers.

Web2 feb. 2024 · This feature makes MEG3 a key lncRNA that modulates different types of genes. MEG3 can function as a ceRNA in tumors . For example, lncRNA MEG3 is less expressed in prostate cancer, which affects cell proliferation, migration, invasion ability and apoptosis rate by regulating miR-9-5p and QKI-5 . Web2 apr. 2012 · MEG3 induces accumulation of p53 (TP53) protein, stimulates transcription from a p53-dependent promoter, and selectively regulates p53 target gene expression. … narrative report for teaching internship

Lnc‐MEG3 inhibits invasion, migration, and epithelial– …

WebHosoya M, Fujioka M1, Murayama AY, Ogawa K, Okano H, Ozawa H: Genes (Basel) 2024/7; 12 (7): 1082. (藤岡正人1: 1分子遺伝) ... Time-course changes in liver functional reserve after successful sofosbuvir/velpatasvir treatment in patients with decompensated cirrhosis. Atsukawa M1, Tsubota A1, Kondo C1, Toyoda H1, Nakamuta M1, Takaguchi ... WebThe genes analyzed included the maternally expressed Igf2r, Ube3, and Meg3/Gtl2 (left side of panel), and the paternally expressed Impact and U2af2-rs1 (right side of panel). ( C ) Conserved methylation status of the H19 differentially methylated region in bone marrow cells of recipients with entirely AG- or GG-derived hematopoietic systems. WebMEG3 is a maternally expressed imprinted gene suggested to function as a non-coding RNA. Our previous studies suggest that MEG3 has a function of tumor suppression. The tumor suppressor p53 plays a central role in tumor suppression and mediates the functions of many other tumor suppressors. Therefore, we hypothesized that MEG3 functions … narrative report in english

The Effect of Metformin and Carbohydrate-Controlled Diet on …

Impact of MEG3 on malignant behavior of HCC OTT - Dove …

WebNew evidence showed is long non-coding RNAs (lncRNAs) play crucial roles in a broad working of biological processed and dysregulated lncRNAs are involved in many complex human afflictions, including cancer. Although a fewer lncRNAs’ functions in cancer have been characterized, the detailed regulatory mechanisms of majority in lncRNAs in cancer … WebMaternally Expressed Gene 3 (MEG3) is a long noncoding RNA (lncRNA) that coordinates a diverse array of cellular processes requiring epigenetic regulation of genes and interactions with key signaling proteins and by acting as a competitive endogenous (ce)RNA. Epigenetic modifications driven by in utero nutrition affect MEG3 expression and its role in the … meldpunt collectief onrecht b.vWebThe MEG3 gene encodes a noncoding RNA of approximately 1700 nucleotides. There are 12 different MEG3 gene transcripts, generated by alternative splicing. They contain … narrative reporting pbcs

"Web23 mei 2024 · Our study explored the functional roles of lncRNA MEG3 in proliferation, apoptosis, migration, and invasion of human placental CC cell line, JEG-3 and BeWo. In addition, the potential downstream factor as well as involved signaling cascades were also explored. 2 MATERIALS AND METHODS 2.1 Cell culture " - Meg3 gene function

Meg3 gene function

Cells Free Full-Text MEG3 Promotes Differentiation of Porcine ...

Web27 okt. 2024 · We aim to investigate the roles and mechanisms of long non-coding RNA maternally expressed gene 3 (lnc-MEG3) in NPC. Methods. The expression levels of lnc-MEG3 and sequestosome 1 (SQSTM1) in NPC tissues and cell lines were detected by quantitative real-time polymerase chain reaction (qRT-PCR). WebAbout. • An experienced scientist with 17+ years research experience in genetics, cellular and molecular biology, tissue culture, CRISPR-Cas9 gene knock out, siRNA, mRNA, epigenetics, T cells ...

Did you know?

Web4 feb. 2024 · Linc00023 is located on chromosome 14q32.2 within the DLK-MEG3 locus and is also widely known as the maternally expressed 3 gene (MEG3). The deregulation of linc00023 was reported to be involved in the progression of various tumours, including meningioma, hepatocellular cancer, breast cancer and BLCA [55,56]. Web15 jun. 2024 · Results: MEG3 was lowly expressed in HCC tissues and cells. Overexpression of MEG3 inhibits the proliferation, migration and invasion of HCC cells. MiR-544b can be sponged by MEG3, and overexpression of miR-544b reverses the anti-cancer effect of MEG3. We further confirmed that BTG2 gene is the target gene of miR-544b.

Web15 feb. 2024 · growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 50- and 30-rapid ampliﬁcation of cDNA ends (RACE) assays, we obtained two di erent variants of lncRNA maternally expressed gene 3 (MEG3), namely, MEG3 Web16 jun. 2024 · of the intergenic regions [47]. MEG3 was identiﬁed to partially associate with the nuclear speckles [37] and since lncRNAs often localize to their site of action, this localization could shed light on the connections of MEG3 to the gene expression pathway. In this study, we examined the dynamics of MEG3 lncRNA in the nucleus of living cells.

WebView unique variants in gene MEG3 View all variants in gene MEG3 Full data view for gene MEG3 Create a new data submission View active genomic custom columns Enable more genomic custom columns View all individuals View all individuals with variants in gene MEG3 Create a new data submission View active custom columns Enable more custom … Web17 jan. 2001 · MEG3: an Oncogenic Long Non-coding RNA in Different Cancers. Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse …

Web1 mrt. 2010 · The MEG3 gene encodes a noncoding RNA of approximately 1700 nucleotides. There are 12 different MEG3 gene transcripts, generated by alternative …

WebFurthermore, Meg3 relied on functional enhancer of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), to inhibit c-Met expression. Another mechanism of lncRNA-mediated regulation of gene expression utilized triplex-forming GA … narrative reporting securityWebThe MEG3 gene encodes a non-coding RNA that functions to suppress tumor cell growth and increase protein expression of the tumor suppressor p53, and selectively activates … narrative reporting web narrative reporting exampleWebConclusion: Our study has identified several key genes involved in bladder cancer. ELF3 and MYBL2 are tumor suppressers, HOXB9 and EN1 are the main regulators, while MEG3, APEX1, and EZH2 are driving factors for bladder cancer progression. Keywords: bladder cancer, differentially expressed genes, tumor driving factor, function analysis. meldpunt fietsroutesWebA maternally expressed gene 3 (MEG3) gene transcripts a 1.6 kb lncRNA whose act as an antitumor component in different cancer cells, such as breast, liver, glioma, colorectal, cervical, gastric, lung, ovarian and osteosarcoma cancer cells. The present review highlights biological function of MEG3 to repress tumor through regulating the narrative reporting meaningWeb1 feb. 2024 · The hypothesis that exosomal MEG3 in urine can be used as a novel diagnostic biomarker for Hunner‐type interstitial cystitis is verified. Toll‐like receptor‐7 (TLR7) is functionally involved in the pathogenesis of Hunner‐type interstitial cystitis (HIC). In addition, maternally expressed gene 3 (MEG3) is implicated in many urethral diseases. … meldpunt fouten basisregistratiesWeb6 apr. 2024 · Preliminary findings suggest that metformin and a carbohydrate-controlled diet improve endometrial function in PCOS patients, partly by modulating DNA methylation of the HOXA10 gene promoter and the expression of genes implicated inendometrial receptivity and insulin signaling. Polycystic ovary syndrome (PCOS) is an endocrine … narrative report in gsp