WebTwo nuclear-encoded vertebrate mitochondrial high-affinity iron importers, mitoferrin1 (Mfrn1) and Mfrn2, have been identified in mammals. In mice, the gene encoding Mfrn1, solute carrier family 25 member 37 ... Placing animals on a low-iron diet exaggerated the reduction in mitochondrial iron observed in liver-specific Mfrn1/2-knockout animals. WebThe biogenesis of iron-sulfur (Fe/S) proteins is conserved from yeast to man, and in mitochondria requires the ISC machinery with 18 known proteins. The mitochondrial …
Reactome SLC25A28 [mitochondrial inner membrane]
Web20 nov. 2024 · We thus conclude that mitochondrial Fe ion supply is an important player in neuronal energy metabolism and proper brain function and that the carrier mitoferrin-1 … WebResults: Lysosomal iron release and mitochondrial iron uptake through mitoferrin-2 (Mfrn2) acted synergistically to induce PDT-mediated and iron-dependent mitochondrial dysfunction and cell killing. Conclusion: Mfrn2 plays a critical … cecilie lund vinther
A review of nemorosone: Chemistry and biological properties
Web20 nov. 2024 · We thus conclude that mitochondrial Fe ion supply is an important player in neuronal energy metabolism and proper brain function and that the carrier mitoferrin-1 cannot be completely replaced by mitoferrin-2 or other as yet unknown Fe ion carriers. Keywords: Brain; Mitoferrin-1; Mitoferrin-2. Copyright © 2024 Elsevier B.V. All rights … WebZebrafish mitoferrin1 (mfrn1), one of two MRS3/4 ortho- cell lines, mbn-dmfrn cells had higher Fer1HCH (ferritin 1 logues, is essential for erythropoiesis, but little is known about heavy chain homologue) transcript and protein levels. RNA the ubiquitously expressed paralogue mfrn2. Webmitoferrin1 (mfrn1)is involved in mitochondrial haem synthesis and is essential for erythropoiesis in zebrafish [22]. Less is known about the ubiquitously expressedmfrn1-paralogue mfrn2. Even though it cannot complement mfrn1mutations in zebrafish, it rescues the MRS3/4yeast mutant [22]. cecilie hother født