Web1 nov. 2024 · Inhibition of CRM1/XPO-1 nuclear export pathway with nuclear export inhibitors can overcome this restriction by trapping restriction factors in the nucleus and … Selective inhibitors of nuclear export (SINEs or SINE compounds) are drugs that block exportin 1 (XPO1 or CRM1), a protein involved in transport from the cell nucleus to the cytoplasm. This causes cell cycle arrest and cell death by apoptosis. Thus, SINE compounds are of interest as anticancer drugs; several are in development, and one (selinexor) has been approved for treatment of multiple myeloma as a drug of last resort.
Frontiers Small Molecule Inhibitors of CRM1
WebMethods: pBECs from healthy participants (n = 5) were CR using gamma-irradiated 3T3 fibroblasts and Rho Kinase inhibitor. CRpBECs were differentiated at ALI in either PneumaCultTM (PN-ALI) or Bronchial Epithelial Growth Medium (BEGM)-based differentiation media (BEBM:DMEM, 50:50, LonzaTM) - (AB-ALI) for 28 days. Web1 feb. 2000 · The nuclear export inhibitor leptomycin B (LMB) sequestered NF-κB/IκBα complexes in the nucleus. Using deletion and site-directed mutagenesis, we identified a previously uncharacterized nuclear export sequence in residues 45–54 of IκBα that was required for cytoplasmic localization of inactive complexes. chmeli suneli poznan
Selinexor-induced thrombocytopenia results from inhibition of ...
Web10 nov. 2024 · Nuclear export of important members of the NF-κB signalling pathway, such as inhibitors of NF-κB (IκB), p65 and p50, can activate this pathway and lead to the … WebAddition of the nuclear export inhibitor selinexor to standard intensive treatment for elderly patients with acute myeloid leukemia and high risk myelodysplastic syndrome — de … WebTherapeutic targeting of nuclear export inhibition in lung cancer. J Thorac Oncol. 2024;12(9):1446-1450. 4. Mor A, White MA, Fontoura BM. Nuclear trafficking in health … chmura google zaloguj