Ptpmt1 hypoxia
WebOct 1, 2015 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose metabolism in human erythroleukemia TF-1 cells. Exposure to hypoxia or DFO treatment results in upregulation of HIF1-α, HIF-2α and Ptpmt1. Only inhibition of HIF-2α by shRNA ... WebJan 26, 2024 · Bao et al. use CRISPR library screening to identify PTPMT1, an important gene for hypoxic survival of HCC cells. PTPMT1 synthesizes cardiolipin, a crucial …
Ptpmt1 hypoxia
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WebNov 4, 2024 · Beneficial effects of miR-150 in vitro and in vivo were linked with PTPMT1-dependent biosynthesis of mitochondrial phospholipid cardiolipin and reduced expression … WebJan 3, 2013 · Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in hematopoietic failure due to changes in the cell cycle and a block in the differentiation of HSCs. Surprisingly, the HSC pool was increased by ∼40-fold in PTPMT1 knockout mice.
WebNov 4, 2024 · Endothelium-targeted miR-150 delivery prevented the disease in Sugen/hypoxia mice, while endothelial knockdown of miR-150 had adverse effects. miR-150 target genes revealed significant associations with PAH pathways, including proliferation, inflammation, and phospholipid signaling, with PTEN-like mitochondrial phosphatase … WebOct 1, 2015 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose …
WebMar 15, 2024 · Download Citation PTPMT1 regulates mitochondrial death through the SLC25A6-NDUFS2 axis in pancreatic cancer cells Pancreatic ductal adenocarcinoma is a highly malignant cancer with poor ... WebNov 1, 2024 · PTPMT1 and car diolipin levels w ere significantly reduced in Suge n/hypoxia mice, while 196 miR-150 supplementation restored their expression to the level seen in healthy mice ( Figure
WebNov 4, 2024 · PTPMT1 and cardiolipin levels were significantly reduced in Sugen/hypoxia mice, while miR-150 supplementation restored their expression to the level seen in healthy …
Webidentify PTPMT1, an important gene for hypoxic survival of HCC cells. PTPMT1 synthesizes cardiolipin, a crucial component of mitochondrial membrane, to maintain mitochondrial integrity, trap electrons, and prevent excessive ROS accumulation under hypoxia. PTPMT1 is a targetable vulnerability to combat hypoxic cancers. Bao et al., 2024, Cell ... jeopardy possessive adjectivesWebMar 19, 2024 · PTPMT1 regulates cardiolipin synthesis and facilitates the assembly of the ETC complexes which alleviates ROS accumulation during hypoxia. Depletion or … pacific drums wikiWebFeb 10, 2015 · Lysates from ptpmt1 +/ ... SDH activity, supercomplex distribution in the mitochondria, and metabolic adaptation of mitochondria to starvation or hypoxia/reoxygenation (Acín-Pérez et al., 2014). Therefore, in addition to increasing glucose uptake by stimulating insulin secretion, PTPMT1 inhibition may increase the rate of … jeopardy play online kidsWebNov 4, 2024 · PTPMT1 and cardiolipin levels were significantly reduced in Sugen/hypoxia mice, while miR-150 supplementation restored their expression to the level seen in healthy mice (Figures 6A–6C). Overexpression of PTPMT1 and miR-150 significantly elevated cardiolipin levels in cultured endothelial cells (p < 0.01 and p < 0.05, respectively) ( Figure … jeopardy play onlineWebHypoxia provokes metabolism misbalance, mitochondrial dysfunction and oxidative stress in both human and animal cells. However, the mechanisms which hypoxia causes mitochondrial dysfunction and energy metabolism misbalance still remain unclear. In … jeopardy powerpoint game template freeWebMar 19, 2024 · PTPMT1 regulates cardiolipin synthesis and facilitates the assembly of the ETC complexes which alleviates ROS accumulation during hypoxia. Depletion or pharmacological inhibition of PTPMT1 decreases tumor growth, disrupts the mitochondrial membrane and ETC formation, and reduced metastasis in different cancers [ 184 ]. jeopardy pop culture for kidsjeopardy powerpoint game with scorekeeper