Receptor tyrosine-protein kinase erbB-2 is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 … Visa mer HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was … Visa mer The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. One of which is erbB-2, and the other members being erbB-1, erbB-3 (neuregulin-binding; … Visa mer HER2 is the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is effective only in cancers where HER2 is over-expressed. One year of … Visa mer HER2/neu has been shown to interact with: • CTNNB1, • DLG4, • Erbin, • GRB2, • HSP90AA1, • IL6ST, Visa mer ERBB2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12). Visa mer Cancer Amplification, also known as the over-expression of the ERBB2 gene, occurs in approximately 15-30% of breast cancers. It is strongly associated with increased disease recurrence and a poor prognosis; however, drug agents … Visa mer HER2 testing is performed on breast biopsy of breast cancer patients to assess prognosis and to determine suitability for trastuzumab therapy. It is important that trastuzumab is … Visa mer WebbTyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous …

ErbB/HER Signaling Cell Signaling Technology

WebbProtein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial cancers. Disruption of Ptk6 decreases azoxymethane-induced colon tumorigenesis in mice by preventing ... WebbHuman papillomavirus 16 E2 interacts with neuregulin receptor degradation protein 1 affecting ErbB-3 expression in vitro and in clinical samples of cervical lesions ☆ Author links open overlay panel Francesca Paolini a b , Gianfranca Curzio a b , Elisa Melucci c , Irene Terrenato d , Barbara Antoniani c , Mariantonia Carosi c , Marcella Mottolese c , … radioimmunoassay immunoassay

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Webberb-b2 receptor tyrosine kinase 3 Synonyms Erbb-3, Erbb3r, HER3 Feature Type protein coding gene IDs MGI:95411 NCBI Gene: 13867 Alliance gene page Transcription Start Sites 7 TSS Location & Maps more Sequence Map Chr10:128403392-128425504 bp, - strand From NCBI annotation of GRCm39 Genetic Map Chromosome 10, 77.10 cM Strain … Webb1 nov. 2004 · Expression of the epidermal growth factor (EGF) and activation of its receptor (EGFR), a tyrosine kinase, are associated with progressive growth of head and neck … Webb20 mars 2014 · HER2, a ligand-free tyrosine kinase receptor of the HER family, is frequently overexpressed in breast cancer. The anti-HER2 antibody trastuzumab has shown … radioimmunoassay (ria) คือ