2024 Triazaacenaphthylene

Triazaacenaphthylene

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August undefined, 2024

WebApr 2, 2024 · Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that may provide a new treatment option for antibiotic-resistant pathogens. Two pharmacokinetic … WebGepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. Gepotidacin is a novel, first-in-class, triazaacenaphthylene antibacterial that …

EAGLE-2 and EAGLE-3 phase III trials for gepotidacin stopped …

WebNov 3, 2024 · Gepotidacin is a novel, investigational bactericidal, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct … WebHow to say triazaacenaphthylene in English? Pronunciation of triazaacenaphthylene with 1 audio pronunciation and more for triazaacenaphthylene. prof. dr. wolfgang schieder

135283-73-7,Dispiro[oxepin-2(3H),4

WebStructure, properties, spectra, suppliers and links for: 1-Thia-5,8,8b-triazaacenaphthylene-4,7(3H,5H)-dione. Neisseria gonorrhoeae, the aetiological agent of the sexually transmitted infection gonorrhoea, remains a significant global public health concern. The WHO estimated in 2012 there were ∼78 million new cases of gonococcal infections among adult women and men globally.1 According to the 2013 global burden … See more Gepotidacin demonstrated in vitro activity against all the tested N. gonorrhoeae isolates (n =252). The susceptibility results for gepotidacin and seven … See more This is the first comprehensive in vitro evaluation of gepotidacin, a novel topoisomerase II inhibitor belonging to the new class of triazaacenaphthylene … See more WebBackground Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action and is active against most strains of Neisseria gonorrhoeae ( N. gonorrhoeae ). Phase II data suggested higher exposures were needed for efficacy and to suppress resistance development. A … prof dr wolfgang brück

EAGLE-2 and EAGLE-3 phase III trials for gepotidacin stopped …

GSK starts a phase III clinical programme for a potential first-in ...

WebOct 29, 2024 · Gepotidacin belongs to the triazaacenaphthylene bacterial topoisomerase inhibitors antibiotic class. The drug specifically acts on the DNA gyrase and … WebFind quality suppliers and manufacturers of 1H-5,6,8b-Triazaacenaphthylene-3-carboxylicacid, 2,2a,3,4,5,7,8,8a-octahydro-4-methyl-7-nonyl-,9-[(3R)-1-amino-4-[[4 ... prof. dr. wolfgang schallerWebGepotidacin. Gepotidacin ( INN [1]) is an experimental antibiotic that acts as a topoisomerase type II inhibitor. [2] It is being studied for the treatment of uncomplicated … prof. dr. wolfgang lücke

"WebOct 28, 2024 · Issued: London, UK. GlaxoSmithKline plc (LSE/NYSE: GSK) today announced that patient dosing has begun in a phase III clinical programme investigating gepotidacin, … " - Triazaacenaphthylene

Triazaacenaphthylene

WebTriazaacenaphthylene C9H5N3 CID 54058133 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... WebJun 26, 2024 · Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor that is being developed for the treatment of uncomplicated …

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WebThe study has been completed, and results are awaited. 159 Gepotidacin (GSK2140944) is a topoisomerase type IIA and DNA gyrase inhibitor, belonging to the class of triazaacenaphthylene antibacterials. 160,161 Gepotidacin was evaluated in a phase 2, randomized study divided into two parts (one open-label and one double-blind), in patients … WebMay 2, 2024 · Gepotidacin 2 NBTI (Triazaacenaphthylene) iv & oral (GSK) Zoliflodacin 2 NBTI (Spiropyrimidenetrione) oral (Entasis/GARDP) ETX2514 + sulbactam 2 DBO-BLI …

WebGepotidacin inhibits Bacterial DNA replication through a mode different from that of fluoroquinolones. Gepotidacin and comparators were tested by broth and agar dilution … WebJun 9, 2009 · Reactions of methyl 3-amino-1H-indole-2-carboxylates with aryl isocyanates, aryl isothiocyanates, and cyanamides led to the formation of 5H-pyrimido[5,4-b]indole derivatives. In the reaction with isocyanates formed 3-aryl-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-diones that were involved into the alkylation at two nitrogen atoms. The …

Web(triazaacenaphthylene bacterial type Research Triangle Park, NC tract infections (uUTI) www.gsk.com II topoisomerase inhibitor) GSK2556286 GlaxoSmithKline Mycobacterium tuberculosis Phase I (Mycobacterium tuberculosis Research Triangle Park, NC www.gsk.com cholesterol dependent inhibitor) GSK3036656 GlaxoSmithKline … WebGepotidacin is a triazaacenaphthylene that is a type II topoisomerase inhibitor [ 26–28 ]. It strongly inhibits the Neisseria gonorrhoeae and other conventional pathogens grown in …

WebMay 25, 2024 · A convenient method for the synthesis of methyl 8-oxo-3H,8H-2a,5a,7-triazaacenaphthylene-2-carboxylate by iodination of 7-allyl-4-methoxypyrrolo[2,3 …

WebJan 15, 2024 · Gepotidacin is a novel triazaacenaphthylene antibiotic in Phase 3 development. Based on nonclinical in vitro characterization of gepotidacin metabolism, two Phase 1 studies were conducted in ... prof. dr. wolfgang luchtWebJNJ-64264681 (JNJ 64264681) Catalog No.: PC-49425 Not For Human Use, Lab Use Only. JNJ-64264681 is a covalent, irreversible BTK inhibitor with potent whole blood activity … religious technology center v netcomWebDec 1, 2024 · Gepotidacin (previously GSK2140944) is a novel, bactericidal, oral, 'first-in-class' triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by blocking … prof. dr. wolfgang schröerWebNov 20, 2012 · An efficient tandem route to the synthesis of 3H-1,2a1,3-triazaacenaphthylene derivatives of the cyclazine family has been developed. Target … prof. dr. wolfgang huberWebJNJ-64264681 (JNJ 64264681) Catalog No.: PC-49425 Not For Human Use, Lab Use Only. JNJ-64264681 is a covalent, irreversible BTK inhibitor with potent whole blood activity and exceptional kinome selectivity. prof. dr. wolfgang reinhartWebJul 26, 2024 · Gepotidacin (GlaxoSmithKline) is another bacterial topoisomerase II inhibitor, a novel triazaacenaphthylene with good in vitro activity against a wide range of drug-resistant bacteria, including MRSA (methicillin-resistant Staphylococcus aureus), ESBL (extended-spectrum β-lactamases)-producing Enterobacteriaceae, and N. gonorrhoeae . prof. dr. wolfgang schmidtWebtriazaacenaphthylene bacterial type II topoisomerase inhibitor COVID-19 anti-spike protein antibody GSK3036656 Tuberculosis Leucyl t-RNA synthetase inhibitor Phase II GSK3228836 Hepatitis B HBV antisense GSK3640254 HIV HIV maturation inhibitor Visceral leishmaniasis CRK-12 inhibitor GSK3882347 FimH antagonist prof. dr. wolfgang schnick